CFBrainAug: Modularity-Induced Counterfactual Brain Network Augmentation for Interpretable fMRI-based Autism Diagnosis

arXiv:2610.32184v1 Announce Type: new Abstract: Machine learning on resting-state functional magnetic resonance imaging (rs-fMRI) brain networks is promising for diagnosing Autism Spectrum Disorder (ASD), but existing methods are prone to overfitting on limited training data, and their post-hoc statistical attribution offers limited clinical interpretability. We propose CFBrainAug, a counterfactual brain network learning framework that unifies data augmentation and counterfactual explanation by learning label-altered brain networks. Unlike conventional label-preserving augmentation, CFBrainAug first retrieves a label-opposite yet topologically similar candidate and then refines it under a module-number constraint. Jointly training on factual and counterfactual networks enriches the trainin