Microsoft’s MAI-DxO system achieves 83% accuracy in diagnosing complex cases, but most of the improvement stems from the underlying large model.
According to research published in Science, Microsoft’s AI diagnostic system MAI-DxO achieved an accuracy of 83% in simulating the diagnosis of complex cases, significantly outperforming general practitioners at 36%; however, analysis indicates that this performance improvement stems primarily from the advanced foundation models it leverages—such as GPT-5.5—while the marginal gains attributable to its proprietary DxO orchestration architecture are limited, and no clear advantages were observed in routine settings like emergency departments.